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An example of
abstract is shown below:
TOWARDS PROTEIN
BASED VACCINES FOR THE PREVENTION OF PNEUMOCOCCAL DISEASES AND
BACTERIAL DIARRHOEA - TWO OF THE MAJOR LIFE-THREATENING CHILDHOOD
INFECTIONS IN THE DEVELOPING WORLD. Andreas Meinke, Eszter Nagy*.
Intercell AG,
Campus Vienna
Biocenter 6, 1030
Vienna ,
Austria
Recombinant protein-based
subunit vaccines have great potential in future vaccinology. The
development of vaccines containing conserved protein antigens offer
advantages in fighting diseases caused by pathogens that are
represented by various different serotypes and preventing infections
with similar clinical manifestation caused by diverse micro-
organisms. Invasive pneumococcal diseases and bacterial diarrhoea
are major cause of death among children in developing countries.
Using the antigenome technology that combines the advantages of full
genome coverage and human serology for high trough-put comprehensive
antigen identification and validation, we have discovered novel
highly conserved pneumococcal antigens that are expressed by all
serotypes, important for in
vivo survival and disease causing potential of Penumococcus.
Such proteins are essential for the development of improved,
broad-coverage pneumococcal vaccines that are avoid of inducing
emergence of non-vaccine serotypes and affordable for the developing
word. The same technology using sera from healthy adults living in
endemic areas identified antigens from the enteric bacteria Shigella flexneri,
enteroaggregative and enterotoxigenic E. coli and Campylobacter jejuni that
are together responsible for the vast majority of diarrhoeal
infections. The combined used of these antigens - some of them
conserved among the different species - has the potential for new
vaccines against life-threatening diarrhoeal diseases among children
living in endemic
areas.
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